#ثريد

راح نتكلم اليوم عن

Chronic kidney disease (CKD)

للمختصين في المجال الصحي

كوب القهوة معاك ☕️ واستمتع ❤️ https://t.co/CK4JARPOpm

def:

is defined as an abnormality of kidney structure or function that persists for > 3 months. https://t.co/WEyW8Yz9iJ

Etiology & pathophysiology:

1- HTN

High BP ➡️ hyaline arteriosclerosis

Decrease O2 delivery ➡️ ischemia ➡️ stimulate mesangial cells (remove trapped residues)➡️ starts to produce TGF-beta (transforming growth factor beta)➡️ lead to fibrosis (glomerulus stenosis)➡️ decrease GFR https://t.co/tqA9riTPf5

2- Diabetes mellitus

High glucose by (non-enzymatic glycosylation) ➡️ attach to protein and lipid ➡️ pre inflammatory molecules ➡️ arteriosclerosis /atherosclerosis – in E.A lead to:

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⁃Decrease O2 lead to tubular diseases which lead to decrease GFR

⁃Increase (back pressure) which increase GFR and lead to activate mesangial cells (decrease GFR). https://t.co/zXEpvK3K2m